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Article

SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice.

Genes & development - 1 Jul 2001

Lindeman G J, Wittlin S, Lada H, Naylor M J, Santamaria M, Zhang J G, Starr R, Hilton D J, Alexander W S, Ormandy C J, Visvader J

Abstract excerpt

Prolactin is essential for proliferation and differentiation of the developing mammary gland. We have explored a role for Suppressor of Cytokine Signaling 1 (SOCS1) as a modulator of the prolactin response using mice deficient in SOCS1, which were rescued from neonatal death by deletion of the Interferon gamma (IFN gamma) gene. SOCS1(-/-)/IFN gamma(-/-) mice exhibited accelerated lobuloalveolar development in the...

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Source

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Identifiers

PMID: 11445538
DOI: 10.1101/gad.880801
PMCID: PMC312725

Genes

SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice.PMID 11445538Read ↗

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The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivoSemantic proximity Read ↗

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Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells.Semantic proximity Read ↗

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A regulatory role for suppressor of cytokine signaling-1 in Th polarization in vivoSemantic proximity Read ↗

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