Article
Prediction of CYP3A4 enzyme activity using haplotype tag SNPs in African Americans.
The pharmacogenomics journal - 1 Feb 2009
Perera M A, Thirumaran R K, Cox N J, Hanauer S, Das S, Brimer-Cline C, Lamba V, Schuetz E G, Ratain M J, Di Rienzo A
Abstract excerpt
The CYP3A locus encodes hepatic enzymes that metabolize many clinically used drugs. However, there is marked interindividual variability in enzyme expression and clearance of drugs metabolized by these enzymes. We utilized comparative genomics and computational prediction of transcriptional factor binding sites to evaluate regions within CYP3A that were most likely to contribute to this variation. We then used a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.