Article
Frequency distribution of cytochrome P450 3A4 gene polymorphism in ethnic populations and in transplant recipients.
Research communications in molecular pathology and pharmacology - 1 Jan 2006
Zhou Xinchun, Barber W Henry, Moore Charles K, Tee Lee Y, Aru Giorgio, Harrison Sebron, Mangilog Brenda, McDaniel D Olga
Abstract excerpt
CYP 3A4 plays a vital role in the metabolism of many drugs including immunosuppressants. An association between a transition of A --> G at position -290 of the 5'-regulatory region of the CYP 3A4 gene and an effect on the level of transcription has been reported. The CYP 3A4-G variant frequency v...
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