Article
Dual Roles for the TSPYL Family in Mediating Serotonin Transport and the Metabolism of Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder.
Clinical pharmacology and therapeutics - 1 Mar 2020
Qin Sisi, Eugene Andy R, Liu Duan, Zhang Lingxin, Neavin Drew, Biernacka Joanna M, Yu Jia, Weinshilboum Richard M, Wang Liewei
Abstract excerpt
We previously reported that testis-specific Y-encoded-like protein (TSPYLs) are transcription regulators for CYP3A4, CYP2C9, and CYP2C19. Here, we observed dual roles for TSPYLs in mediating serotonin transport and the metabolism of selective serotonin reuptake inhibitors (SSRIs) in patients with major depressive disorder (MDD). The widely prescribed SSRIs, citalopram, and escitalopram are metabolized mainly by...
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