Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of CYP3A variants with kidney transplant outcomes.

Renal failure - 1 May 2015

Traynor Carol, Conlon Peter, Phelan Paul J, O'Kelly Patrick, Elens Laure, McCormack Mark, Cavalleri Gianpiero, Comber Harry, van Schaik R H N, Conlon Peter J

Abstract excerpt

Cyclosporine is used extensively in kidney transplantation and is a substrate for cytochrome P450 enzymes. The role of cytochrome p450 polymorphisms in kidney transplant outcome has not yet been fully elucidated. We investigate the clinical impact of single nucleotide polymorphisms in CYP3A4, CYP3A5, PPARα, and POR*28 in 255 kidney transplant recipients. We examine for any association with graft survival, time to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytochrome P-450 CYP3A
Share to POR gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Graft Survival

Share to Kidney Transplantation

Share to Neoplasms

Share to Polymorphism, Single Nucleotide

Share to Postoperative Complications

Share to Treatment Outcome

Source

Identifiers

PMID: 25644970
DOI: 10.3109/0886022X.2015.1007013

Genes

POR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of CYP3A variants with kidney transplant outcomes.PMID 25644970Read ↗

The new CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with an increased risk of delayed graft function and worse renal function in cyclosporine-treated kidney transplant patients.Semantic proximity Read ↗

The influence of CYP3A, PPARA, and POR genetic variants on the pharmacokinetics of tacrolimus and cyclosporine in renal transplant recipients.Semantic proximity Read ↗

Genetic polymorphisms and kidney transplant outcomes.Semantic proximity Read ↗

CYP2C8*3 polymorphism and donor age are associated with allograft dysfunction in kidney transplant recipients treated with calcineurin inhibitors.Semantic proximity Read ↗

Association of UGT2B7, UGT1A9, ABCG2, and IL23R polymorphisms with rejection risk in kidney transplant patients.Semantic proximity Read ↗

Genetic prediction of renal transplant outcomeSemantic proximity Read ↗

Single Nucleotide Polymorphisms and Long-Term Clinical Outcome in Renal Transplant Patients: A Validation Study.Semantic proximity Read ↗

Genetic determinants of renal transplant outcome: where do we stand?Semantic proximity Read ↗

Donor CYP3A5 Expression Decreases Renal Transplantation Outcomes in White Renal Transplant Recipients.Semantic proximity Read ↗

Pharmacogenetics of post-transplant diabetes mellitus in children with renal transplantation treated with tacrolimus.Semantic proximity Read ↗

Lack of Relationship Between Renal Function and Genetic Variants of CYP3A4, CYP3A5, MDR1, MRP2, UGT1A9, UGT1A8, and UGT2B7 in Patients After Liver Transplantation in a 2-Year Follow-up.Semantic proximity Read ↗

Importance of genetic polymorphisms in liver transplantation outcomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.