Article
Lupus Susceptibility Region Containing CDKN1B rs34330 Mechanistically Influences Expression and Function of Multiple Target Genes, Also Linked to Proliferation and Apoptosis.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Dec 2021
Singh Bhupinder, Maiti Guru P, Zhou Xujie, Fazel-Najafabadi Mehdi, Bae Sang-Cheol, Sun Celi, Terao Chikashi, Okada Yukinori, Heng Chua Kek, Kochi Yuta, Guthridge Joel M, Zhang Hong, Weirauch Matthew, James Judith A, Harley John B, Varshney Gaurav K, Looger Loren L, Nath Swapan K
Abstract excerpt
OBJECTIVE: In a recent genome-wide association study, a significant genetic association between rs34330 of CDKN1B and risk of systemic lupus erythematosus (SLE) in Han Chinese was identified. This study was undertaken to validate the reported association and elucidate the biochemical mechanisms underlying the effect of the variant. METHODS: We performed an allelic association analysis in patients with SLE,...
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