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Article

Metabolomic ageing (MileAge) in mid-life predicts incident vascular, unspecified and all-cause dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2026

Mutz Julian, Gilchrist Lachlan, Pain Oliver, Proitsi Petroula, Lewis Cathryn M

Abstract excerpt

INTRODUCTION: Identifying individuals at risk of dementia is essential for prevention and targeted disease-modifying strategies. We investigated whether mid-life metabolomic ageing is associated with incident dementia and its age of onset and assessed joint associations and interactions with APOE genotype and dementia polygenic scores. METHODS: In the UK Biobank, plasma metabolites were quantified at baseline....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42126002
DOI: 10.1002/alz.71280
PMCID: PMC13169133

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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