Next-generation sequencing reveals high concordance of recurrent somatic alterations between primary tumor and metastases from patients with non-small-cell lung cancer.

doi:10.1200/JCO.2012.47.7737

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Article

Next-generation sequencing reveals high concordance of recurrent somatic alterations between primary tumor and metastases from patients with non-small-cell lung cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Jun 2013

Vignot Stéphane, Frampton Garrett M, Soria Jean-Charles, Yelensky Roman, Commo Frédéric, Brambilla Christian, Palmer Gary, Moro-Sibilot Denis, Ross Jeffrey S, Cronin Maureen T, André Fabrice, Stephens Philip J, Lazar Vladimir, Miller Vincent A, Brambilla Elisabeth

Abstract excerpt

PURPOSE: Characterization of the genomic changes that drive an individual patient's disease is critical in management of many cancers. In patients with non-small-cell lung cancer (NSCLC), obtaining tumor samples of sufficient size for genomic profiling on recurrence is often challenging. We undertook this study to compare genomic alterations identified in archived primary tumors from patients with NSCLC with...

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PMID: 23630207
DOI: 10.1200/JCO.2012.47.7737

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