Article
Major driver mutations are shared between sinonasal intestinal-type adenocarcinoma and the morphologically identical colorectal adenocarcinoma.
Journal of cancer research and clinical oncology - 1 Apr 2021
Sjöstedt Sannia, Schmidt Ane Yde, Vieira Filipe Garrett, Willemoe Gro Linno, Agander Tina Klitmøller, Olsen Caroline, Nielsen Finn Cilius, von Buchwald Christian
Abstract excerpt
PURPOSE: The purpose of our study was to compare genomic changes in sinonasal intestinal-type adenocarcinoma (sITAC) and colorectal adenocarcinoma (CRC), as they are histomorphologically indistinguishable. This can cause diagnostic difficulties as sinonasal tumours initially diagnosed as sITAC may represent metastasis from CRC, a frequent cancer. Previous studies have not uncovered the underlying mechanism behind...
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