Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The mutational landscape of recurrent versus nonrecurrent human papillomavirus-related oropharyngeal cancer.

JCI insight - 26 Jul 2018

Harbison R Alex, Kubik Mark, Konnick Eric Q, Zhang Qing, Lee Seok-Geun, Park Heuijoon, Zhang Jianan, Carlson Christopher S, Chen Chu, Schwartz Stephen M, Rodriguez Cristina P, Duvvuri Umamaheswar, Méndez Eduardo

Abstract excerpt

BACKGROUND: Human papillomavirus-related (HPV-related) oropharyngeal squamous cell carcinomas (OPSCCs) have an excellent response rate to platinum-based chemoradiotherapy. Genomic differences between primary HPV-related OPSCCs that do or do not recur are unknown. Furthermore, it is unclear if HPV-related OPSCCs that recur share a genomic landscape with HPV-negative head and neck cancers (HNCs). METHODS: We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Copy Number Variations
Share to Genes, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Recurrence, Local

Share to Oropharyngeal Neoplasms

Share to Papillomaviridae

Share to Papillomavirus Infections

Share to Squamous Cell Carcinoma of Head and Neck

Share to United States

Source

Open in PubMed Open full text

Identifiers

PMID: 30046007
DOI: 10.1172/jci.insight.99327
PMCID: PMC6124437

Genes

AJUBA
BRIP1
CASP8
FAT1
KMT2D
NBN
NFE2L2
NSD1
TP53
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The mutational landscape of recurrent versus nonrecurrent human papillomavirus-related oropharyngeal cancer.PMID 30046007Read ↗

Mutation patterns in recurrent and/or metastatic oropharyngeal squamous cell carcinomas in relation to human papillomavirus status.Semantic proximity Read ↗

The molecular characteristics of recurrent/metastatic HPV-positive head and neck squamous cell carcinoma: A systematic review of the literatureSemantic proximity Read ↗

Improved outcomes in PI3K-pathway-altered metastatic HPV oropharyngeal cancer.Semantic proximity Read ↗

Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma.Semantic proximity Read ↗

Targeted Molecular Sequencing of Recurrent and Multifocal Non-HPV-associated Squamous Cell Carcinoma of the Vulva.Semantic proximity Read ↗

Human Papilloma Virus Associated Oropharyngeal Squamous Cell Carcinoma: Epidemiological and Biological Factors Associated with Local and Distant RecurrenceSemantic proximity Read ↗

Clinical, morphologic and molecular heterogeneity of HPV-associated oropharyngeal cancerSemantic proximity Read ↗

Molecular landscape of head and neck cancer and implications for therapySemantic proximity Read ↗

Association of oropharyngeal cancer recurrence with tumor-intrinsic and immune-mediated sequelae of reduced genomic instabilitySemantic proximity Read ↗

Comparison of mutation landscapes of pretreatment versus recurrent squamous cell carcinoma of the oral cavity: The possible mechanism of resistance to standard treatment.Semantic proximity Read ↗

Comparative genomic analysis of oral versus laryngeal and pharyngeal cancerSemantic proximity Read ↗

Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.