Article
Circulating Tumor DNA Profiling Reveals Genomic Evolution in Recurrent Gastric or Gastroesophageal Junction Cancer.
Molecular diagnosis & therapy - 1 Nov 2025
Kawabata Ryohei, Takeda Hiroyuki, Ishiguro Atsushi, Nishina Shinichi, Takahashi Masazumi, Suzuki Shuhei, Suzuki Takahisa, Matsuyama Jin, Otsuki Yasufumi, Akamaru Yusuke, Takegawa Naoki, Nomura Takashi, Kito Yosuke, Yabusaki Hiroshi, Negoro Yuji, Makiyama Akitaka, Nakamura Masato, Takahashi Masaki, Sunakawa Yu
Abstract excerpt
BACKGROUND: Recurrent gastric or gastroesophageal junction cancers have poor prognoses and limited treatment options. While archival tumor tissue is commonly used for genomic profiling, it may not reflect molecular changes at recurrence. OBJECTIVE: We aimed to assess the utility of a circulating tumor DNA analysis in identifying actionable genomic alterations at recurrence and compare findings with archival...
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