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Article

Next-generation sequencing for identification of actionable gene mutations in intestinal-type sinonasal adenocarcinoma.

Scientific reports - 26 Jan 2021

Sánchez-Fernández Paula, Riobello Cristina, Costales María, Vivanco Blanca, Cabal Virginia N, García-Marín Rocío, Suárez-Fernández Laura, López Fernando, Cabanillas Rubén, Hermsen Mario A, Llorente José Luis

Abstract excerpt

Intestinal-type sinonasal adenocarcinoma (ITAC) is a rare tumor carrying poor prognosis and needing new treatment options. The aim of this study was to identify actionable gene mutations that can guide new personalized target-specific therapies in ITAC patients. A series of 48 tumor and 27 corresponding germline DNA samples were analyzed by next generation sequencing using a panel of 120 genes. In total, 223...

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Source

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Identifiers

PMID: 33500480
DOI: 10.1038/s41598-020-80242-z
PMCID: PMC7838394

Genes

APC
ATM
BRCA1
KRAS
LRP1B
NF1
PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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