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Predicting proximal tubule failed repair drivers through regularized regression analysis of single cell multiomic sequencing

12 Feb 2024

Abstract excerpt

Renal proximal tubule epithelial cells have considerable intrinsic repair capacity following injury. However, a fraction of injured proximal tubule cells fails to undergo normal repair and assumes a proinflammatory and profibrotic phenotype that may promote fibrosis and chronic kidney disease. The healthy to failed repair change is marked by cell state-specific transcriptomic and epigenomic changes. Single...

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PMID: 38347009
DOI: 10.1038/s41467-024-45706-0

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