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Predicting regulators of epithelial cell state through regularized regression analysis of single cell multiomic sequencing

2022-12-30

Abstract excerpt

Chronic disease processes are marked by cell-specific transcriptomic and epigenomic changes. Single nucleus joint RNA- and ATAC-seq offers an opportunity to study the gene regulatory networks underpinning these changes in order to identify key regulatory drivers. We developed a regularized regression approach, RENIN, ( Re gulatory N etwork In ference) to construct genome-wide parametric gene regulatory networks...

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Literature Corpus work
2e57eb36-9029-554e-88d4-6b39637dcc6c
DOI
10.1101/2022.12.29.522232
Open publication

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Predicting regulators of epithelial cell state through regularized regression analysis of single cell multiomic sequencingDOI 10.1101/2022.12.29.522232
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