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Epigenetic reprogramming driving successful and failed repair in acute kidney injury

7 Aug 2024

Abstract excerpt

Acute kidney injury (AKI) causes epithelial damage followed by subsequent repair. While successful repair restores kidney function, this process is often incomplete and can lead to chronic kidney disease (CKD) in a process called failed repair. To better understand the epigenetic reprogramming driving this AKI-to-CKD transition, we generated a single-nucleus multiomic atlas for the full mouse AKI time course,...

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PMID: 39110788
DOI: 10.1126/sciadv.ado2849

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