Article
Molecular Phenotypes of Acute Respiratory Distress Syndrome in the ROSE Trial Have Differential Outcomes and Gene Expression Patterns That Differ at Baseline and Longitudinally over Time.
American journal of respiratory and critical care medicine - 1 Apr 2024
Sinha Pratik, Neyton Lucile, Sarma Aartik, Wu Nelson, Jones Chayse, Zhuo Hanjing, Liu Kathleen D, Sanchez Guerrero Estella, Ghale Rajani, Love Christina, Mick Eran, Delucchi Kevin L, Langelier Charles R, Thompson B Taylor, Matthay Michael A, Calfee Carolyn S
Abstract excerpt
Rationale: Two molecular phenotypes have been identified in acute respiratory distress syndrome (ARDS). In the ROSE (Reevaluation of Systemic Early Neuromuscular Blockade) trial of cisatracurium in moderate to severe ARDS, we addressed three unanswered questions: 1) Do the same phenotypes emerge in a more severe ARDS cohort with earlier recruitment; 2) Do phenotypes respond differently to neuromuscular blockade?...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.