Article
Acute Respiratory Distress Syndrome Molecular Phenotypes Have Distinct Lower Respiratory Tract Transcriptomes.
American journal of respiratory and critical care medicine - 1 Dec 2025
Sarma Aartik, Christenson Stephanie A, Shoshana Beth Zha, Oliveira Angela Pisco, Neyton Lucile P A, Mick Eran, Sinha Pratik, Wilson Jennifer G, Moazed Farzad, Leligdowicz Aleksandra, Maddali Manoj V, Siegel Emily R, Lyon Zoe M, Carrillo Sidney Haller, Zhou Hanjing, Jauregui Alejandra, Ghale Rajani, Caldera Saharai, Hayakawa Paula Serpa, Deiss Thomas, Love Christina, Byrne Ashley, Kalantar Katrina L, DeRisi Joseph L, Erle David J, Krummel Matthew F, Kangelaris Kirsten N, Hendrickson Carolyn M, Woodruff Prescott G, Matthay Michael A, Bos Lieuwe D J, Langelier Charles R, Calfee Carolyn S
Abstract excerpt
Rationale: Two molecular phenotypes of the acute respiratory distress syndrome (ARDS) with divergent clinical trajectories and responses to therapy have been identified. Classification as "hyperinflammatory" or "hypoinflammatory" depends on plasma biomarker profiling. Limited data are available about the differences in the pulmonary biology of the molecular phenotypes. Objectives: To identify differences in the...
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