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Article

Major HBV splice variant encoding a novel protein important for infection.

Journal of hepatology - 1 Jun 2024

Chung Chen-Yen, Sun Cheng-Pu, Tao Mi-Hua, Wu Hui-Lin, Wang Sheng-Han, Yeh Shiou-Hwei, Zheng Qing-Bing, Yuan Quan, Xia Ning-Shao, Ogawa Kenji, Nakashima Kenji, Suzuki Tetsuro, Chen Pei-Jer

Abstract excerpt

BACKGROUND & AIMS: HBV expresses more than 10 spliced RNAs from the viral pregenomic RNA, but their functions remain elusive and controversial. To address the function of HBV spliced RNAs, we generated splicing-deficient HBV mutants and conducted experiments to assess the impact of these mutants on HBV infection. METHODS: HepG2-NTCP cells, human hepatocyte chimeric FRG mice (hu-FRG mice), and serum from patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38336347
DOI: 10.1016/j.jhep.2024.01.037

Genes

SP1
IMPACT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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