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Article

The in vitro replication phenotype of hepatitis B virus (HBV) splice variants Sp3 and Sp9 and their impact on wild-type HBV replication.

Journal of virology - 16 Apr 2024

McCoullough Laura C, Sadauskas Tomas, Sozzi Vitina, Mak Kai Yan, Mason Hugh, Littlejohn Margaret, Revill Peter A

Abstract excerpt

Prior to nuclear export, the hepatitis B virus (HBV) pregenomic RNA may be spliced by the host cell spliceosome to form shorter RNA sequences known as splice variants. Due to deletions in the open reading frames, splice variants may encode novel fusion proteins. Although not essential for HBV replication, the role of splice variants and their novel fusion proteins largely remains unknown. Some splice variants and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38501924
DOI: 10.1128/jvi.01538-23
PMCID: PMC11019940

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