Replication and Expression of the Consensus Genome of Hepatitis B Virus Genotype C from the Chinese Population.

doi:10.3390/v15122302

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Article

Replication and Expression of the Consensus Genome of Hepatitis B Virus Genotype C from the Chinese Population.

Viruses - 23 Nov 2023

Liao Fenfang, Xie Junmou, Du Rongsong, Gao Wenbo, Lan Lanyin, Wang Min, Rong Xia, Fu Yongshui, Wang Hao

Abstract excerpt

Hepatitis B virus (HBV) genotype C is a prevalent HBV genotype in the Chinese population. Although genotype C shows higher sequence heterogeneity and more severe liver disease than other genotypes, its pathogenesis and immunological traits are not yet fully elucidated. In this study, we first established and chemically synthesized the consensus sequence based on representative 138 full-length HBV genotype C...

Topics

Mice
Animals
Hepatitis B virus
Hepatitis B Surface Antigens
Hepatitis B Core Antigens
CD8-Positive T-Lymphocytes
Virus Replication
Genotype
Mice, Inbred BALB C
China
DNA, Viral
Hepatitis B

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Identifiers

PMID: 38140543
DOI: 10.3390/v15122302
PMCID: PMC10747539

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