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Article

Heightened potency of human pluripotent stem cell lines created by transient BMP4 exposure.

Proceedings of the National Academy of Sciences of the United States of America - 5 May 2015

Yang Ying, Adachi Katsuyuki, Sheridan Megan A, Alexenko Andrei P, Schust Danny J, Schulz Laura C, Ezashi Toshihiko, Roberts R Michael

Abstract excerpt

Human pluripotent stem cells (PSCs) show epiblast-type pluripotency that is maintained with ACTIVIN/FGF2 signaling. Here, we report the acquisition of a unique stem cell phenotype by both human ES cells (hESCs) and induced pluripotent stem cells (iPSCs) in response to transient (24-36 h) exposure...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25870291
DOI: 10.1073/pnas.1504778112
PMCID: PMC4426460

Genes

FGF2
BMP4
NANOG
CDX2
LEFTY1
LEFTY2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25870291-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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