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The product of BMP-directed differentiation protocols for human primed pluripotent stem cells is placental trophoblast and not amnion

19 May 2022

Abstract excerpt

The observation that trophoblast (TB) can be generated from primed pluripotent stem cells (PSCs) by exposure to bone morphogenetic protein-4 (BMP4) when FGF2 and ACTIVIN signaling is minimized has recently been challenged with the suggestion that the procedure instead produces amnion. Here, by analyzing transcriptome data from multiple sources, including bulk and single-cell data, we show that the BMP4 procedure...

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PMID: 35594861
DOI: 10.1016/j.stemcr.2022.04.014

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