Article

Chemoresistome Mapping in Individual Breast Cancer Patients Unravels Diversity in Dynamic Transcriptional Adaptation

2023-02-10

Abstract excerpt

Emerging evidence reinforce the role of non-genetic adaptive resistance to chemotherapy, that involves rewiring of transcriptional programs in surviving tumors. We combined longitudinal transcriptomics with temporal pattern analysis to dissect patient-specific emergence of resistance in breast cancer. Matched triplets of tumor biopsies (pre-treatment, post-treatment and adjacent normal) were collected from breast...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1fb6f5cc-ddbb-5882-81a4-26eb267094a8
DOI: 10.1101/2023.02.09.527790

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Chemoresistome Mapping in Individual Breast Cancer Patients Unravels Diversity in Dynamic Transcriptional AdaptationDOI 10.1101/2023.02.09.527790Read

Combating subclonal evolution of resistant cancer phenotypes.Semantic proximity Read

Transcriptional landscape associated with TNBC resistance to neoadjuvant chemotherapy revealed by single-cell RNA-seqSemantic proximity Read

Cellular adaptation to cancer therapy along a resistance continuum.Semantic proximity Read

Computational quantification and characterization of independently evolving cellular subpopulations within tumors is critical to inhibit anti-cancer therapy resistanceSemantic proximity Read

Mapping the Pathways of Resistance to Targeted TherapiesSemantic proximity Read

Therapy resistance: opportunities created by adaptive responses to targeted therapies in cancerSemantic proximity Read

A Multimodal Framework to Uncover Drug-Responsive Subpopulations in Triple-Negative Breast CancerSemantic proximity Read

Spatial transcriptomics reveals influence of microenvironment on intrinsic fates in melanoma therapy resistanceSemantic proximity Read

An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancerSemantic proximity Read

Single-cell decoding of drug induced transcriptomic reprogramming in triple negative breast cancersSemantic proximity Read

An Omic and Multidimensional Spatial Atlas from Serial Biopsies of an Evolving Metastatic Breast CancerSemantic proximity Read

Deciphering the gene regulatory circuitry governing chemoresistance in Triple-Negative Breast CancerSemantic proximity Read