Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The effect of dietary fish oil on weight gain and insulin sensitivity is dependent on APOE genotype in humanized targeted replacement mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2017

Slim Kenna E, Vauzour David, Tejera Noemi, Voshol Peter J, Cassidy Aedin, Minihane Anne Marie

Abstract excerpt

We investigated the independent and interactive impact of the common APOE genotype and marine n-3 polyunsaturated fatty acids (PUFAs) on the development of obesity and associated cardiometabolic dysfunction in a murine model. Human APOE3 and APOE4 targeted replacement mice were fed either a control high-fat diet (HFD) or an HFD supplemented with 3% n-3 PUFAs from fish oil (HFD + FO) for 8 wk. We established the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoproteins E
Share to Diet, High-Fat

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fish Oils

Share to Insulin Resistance

Share to Intra-Abdominal Fat

Share to Obesity

Share to Weight Gain

Source

Open in PubMed Open full text

Identifiers

PMID: 27895108
DOI: 10.1096/fj.201600921RR
PMCID: PMC5295733

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The effect of dietary fish oil on weight gain and insulin sensitivity is dependent on APOE genotype in humanized targeted replacement mice.PMID 27895108Read ↗

Apolipoprotein E (APOE) genotype regulates body weight and fatty acid utilization-Studies in gene-targeted replacement mice.Semantic proximity Read ↗

Apolipoprotein E isoforms disrupt long-chain fatty acid distribution in the plasma, the liver and the adipose tissue of mice.Semantic proximity Read ↗

Effects of the ApoE genotype on cognitive function in aging mice fed with a high-fat diet and the protective potential of n-3 polyunsaturated fatty acids.Semantic proximity Read ↗

Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis.Semantic proximity Read ↗

Understanding hyperlipidemia and atherosclerosis: lessons from genetically modified apoe and ldlr mice.Semantic proximity Read ↗

High-Fat Diet Changes Hippocampal Apolipoprotein E (ApoE) in a Genotype- and Carbohydrate-Dependent Manner in Mice.Semantic proximity Read ↗

The PNPLA3 variant I148M reveals protective effects toward hepatocellular carcinoma in mice via restoration of omega-3 polyunsaturated fats.Semantic proximity Read ↗

Effect of apoE genotype and dietary quercetin on blood lipids and TNF-alpha levels in apoE3 and apoE4 targeted gene replacement mice.Semantic proximity Read ↗

ApoE knockout rabbits: A novel model for the study of human hyperlipidemia.Semantic proximity Read ↗

Human apolipoprotein E allele and docosahexaenoic acid intake modulate peripheral cholesterol homeostasis in mice.Semantic proximity Read ↗

Adulthood dietary exposure to a common pesticide leads to an obese-like phenotype and a diabetic profile in apoE3 mice.Semantic proximity Read ↗

APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.