Polygenic risk scores mediating functioning outcomes through cognitive and clinical features in youth at family risk and controls.

doi:10.1016/j.euroneuro.2024.01.009

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Article

Polygenic risk scores mediating functioning outcomes through cognitive and clinical features in youth at family risk and controls.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Apr 2024

Segura Alex G, Serna Elena de la, Sugranyes Gisela, Baeza Inmaculada, Valli Isabel, Martínez-Serrano Irene, Díaz-Caneja Covadonga M, Andreu-Bernabeu Álvaro, Moreno Dolores M, Gassó Patricia, Rodríguez Natalia, Martínez-Pinteño Albert, Prohens Llucia, Torrent Carla, García-Rizo Clemente, Mas Sergi, Castro-Fornieles Josefina

Abstract excerpt

Schizophrenia and bipolar disorder exhibit substantial clinical overlap, particularly in individuals at familial high risk, who frequently present sub-threshold symptoms before the onset of illness. Severe mental disorders are highly polygenic traits, but their impact on the stages preceding the manifestation of mental disorders remains relatively unexplored. Our study aimed to examine the influence of polygenic...

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PMID: 38310718
DOI: 10.1016/j.euroneuro.2024.01.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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