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Polygenic risk scores and the prediction of onset of mood and psychotic disorders in adolescents and young adults.

Early intervention in psychiatry - 1 Jun 2024

Scott Jan, Crouse Jacob J, Medland Sarah, Byrne Enda, Iorfino Frank, Mitchell Brittany, Gillespie Nathan A, Martin Nicholas, Wray Naomi, Hickie Ian B

Abstract excerpt

AIM: To examine whether polygenic risk scores (PRS) for neuroticism, depression, bipolar disorder and schizophrenia are higher in individuals manifesting trans-diagnostic risk factors for the development of major mental disorders and whether PRS enhance prediction of early onset full-threshold disorders. METHODS: Using data from the Brisbane Longitudinal Twin Study, we examined individual PRS for neuroticism,...

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Identifiers

PMID: 37787636
DOI: 10.1111/eip.13472
PMCID: PMC11100301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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