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Article

Combined polygenic risk scores of different psychiatric traits predict general and specific psychopathology in childhood.

Journal of child psychology and psychiatry, and allied disciplines - 1 Jun 2022

Neumann Alexander, Jolicoeur-Martineau Alexia, Szekely Eszter, Sallis Hannah M, O'Donnel Kieran, Greenwood Celia M T, Levitan Robert, Meaney Michael J, Wazana Ashley, Evans Jonathan, Tiemeier Henning

Abstract excerpt

BACKGROUND: Polygenic risk scores (PRSs) operationalize genetic propensity toward a particular mental disorder and hold promise as early predictors of psychopathology, but before a PRS can be used clinically, explanatory power must be increased and the specificity for a psychiatric domain established. To enable early detection, it is crucial to study these psychometric properties in childhood. We examined whether...

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Identifiers

PMID: 34389974
DOI: 10.1111/jcpp.13501
PMCID: PMC9291767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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