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Article

Pre-existing subclones determine radioresistance in rectal cancer organoids

1 Feb 2024

Abstract excerpt

More than half of all patients with cancer receive radiation therapy, but resistance is commonly observed. Currently, it is unknown whether resistance to radiation therapy is acquired or inherently present. Here, we employed organoids derived from rectal cancer and single-cell whole-genome sequencing to investigate the long-term evolution of subclones in response to radiation. Comparing single-cell whole-genome...

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PMID: 38310513
DOI: 10.1016/j.celrep.2024.113735

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