Article
Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids.
Nature genetics - 1 May 2019
Bolhaqueiro Ana C F, Ponsioen Bas, Bakker Bjorn, Klaasen Sjoerd J, Kucukkose Emre, van Jaarsveld Richard H, Vivié Judith, Verlaan-Klink Ingrid, Hami Nizar, Spierings Diana C J, Sasaki Nobuo, Dutta Devanjali, Boj Sylvia F, Vries Robert G J, Lansdorp Peter M, van de Wetering Marc, van Oudenaarden Alexander, Clevers Hans, Kranenburg Onno, Foijer Floris, Snippert Hugo J G, Kops Geert J P L
Abstract excerpt
Chromosome segregation errors cause aneuploidy and genomic heterogeneity, which are hallmarks of cancer in humans. A persistent high frequency of these errors (chromosomal instability (CIN)) is predicted to profoundly impact tumor evolution and therapy response. It is unknown, however, how prevalent CIN is in human tumors. Using three-dimensional live-cell imaging of patient-derived tumor organoids (tumor PDOs),...
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