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Targeting cancer drug resistance utilizing organoid technology

16 Dec 2022

Abstract excerpt

Cancer organoids generated from 3D in vitro cell cultures have contributed to the study of drug resistance. Maintenance of genomic and transcriptomic similarity between organoids and parental cancer allows organoids to have the ability of accurate prediction in drug resistance testing. Protocols of establishing therapy-sensitive and therapy-resistant organoids are concluded in two aspects, which are generated...

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PMID: 36528918
DOI: 10.1016/j.biopha.2022.114098

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