Article
Biological basis of extensive pleiotropy between blood traits and cancer risk.
Genome medicine - 2 Feb 2024
Pardo-Cea Miguel Angel, Farré Xavier, Esteve Anna, Palade Joanna, Espín Roderic, Mateo Francesca, Alsop Eric, Alorda Marc, Blay Natalia, Baiges Alexandra, Shabbir Arzoo, Comellas Francesc, Gómez Antonio, Arnan Montserrat, Teulé Alex, Salinas Monica, Berrocal Laura, Brunet Joan, Rofes Paula, Lázaro Conxi, Conesa Miquel, Rojas Juan Jose, Velten Lars, Fendler Wojciech, Smyczynska Urszula, Chowdhury Dipanjan, Zeng Yong, He Housheng Hansen, Li Rong, Van Keuren-Jensen Kendall, de Cid Rafael, Pujana Miquel Angel
Abstract excerpt
BACKGROUND: The immune system has a central role in preventing carcinogenesis. Alteration of systemic immune cell levels may increase cancer risk. However, the extent to which common genetic variation influences blood traits and cancer risk remains largely undetermined. Here, we identify pleiotropic variants and predict their underlying molecular and cellular alterations. METHODS: Multivariate Cox regression was...
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