Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci.

doi:10.1038/srep41071

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Article

Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci.

Scientific reports - 23 Jan 2017

Law Philip J, Sud Amit, Mitchell Jonathan S, Henrion Marc, Orlando Giulia, Lenive Oleg, Broderick Peter, Speedy Helen E, Johnson David C, Kaiser Martin, Weinhold Niels, Cooke Rosie, Sunter Nicola J, Jackson Graham H, Summerfield Geoffrey, Harris Robert J, Pettitt Andrew R, Allsup David J, Carmichael Jonathan, Bailey James R, Pratt Guy, Rahman Thahira, Pepper Chris, Fegan Chris, von Strandmann Elke Pogge, Engert Andreas, Försti Asta, Chen Bowang, Filho Miguel Inacio da Silva, Thomsen Hauke, Hoffmann Per, Noethen Markus M, Eisele Lewin, Jöckel Karl-Heinz, Allan James M, Swerdlow Anthony J, Goldschmidt Hartmut, Catovsky Daniel, Morgan Gareth J, Hemminki Kari, Houlston Richard S

Abstract excerpt

B-cell malignancies (BCM) originate from the same cell of origin, but at different maturation stages and have distinct clinical phenotypes. Although genetic risk variants for individual BCMs have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not been performed. We explored genome-wide association studies of chronic lymphocytic leukaemia (CLL, N = 1,842), Hodgkin lymphoma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adaptor Proteins, Signal Transducing

Share to Genetic Pleiotropy

Share to HLA-DQ beta-Chains

Share to HLA-DRB1 Chains

Share to Hodgkin Disease

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Multiple Myeloma

Share to Oncogene Proteins

Source

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Identifiers

PMID: 28112199
DOI: 10.1038/srep41071
PMCID: PMC5253627

Genes

NCK1

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