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Article

Identification of Pleiotropic Cancer Susceptibility Variants from Genome-Wide Association Studies Reveals Functional Characteristics.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2018

Wu Yi-Hsuan, Graff Rebecca E, Passarelli Michael N, Hoffman Joshua D, Ziv Elad, Hoffmann Thomas J, Witte John S

Abstract excerpt

Background: There exists compelling evidence that some genetic variants are associated with the risk of multiple cancer sites (i.e., pleiotropy). However, the biological mechanisms through which the pleiotropic variants operate are unclear.Methods: We obtained all cancer risk associations from the National Human Genome Research Institute-European Bioinformatics Institute GWAS Catalog, and correlated cancer risk...

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Identifiers

PMID: 29150481
DOI: 10.1158/1055-9965.EPI-17-0516
PMCID: PMC5760292

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ELL2

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