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Article

Cross-cancer pleiotropic analysis identifies three novel genetic risk loci for colorectal cancer.

Human molecular genetics - 5 Jun 2023

Sun Jing, Wang Lijuan, Zhou Xuan, Hu Lidan, Yuan Shuai, Bian Zilong, Chen Jie, Zhu Yingshuang, Farrington Susan M, Campbell Harry, Ding Kefeng, Zhang Dongfeng, Dunlop Malcolm G, Theodoratou Evropi, Li Xue

Abstract excerpt

BACKGROUND: To understand the shared genetic basis between colorectal cancer (CRC) and other cancers and identify potential pleiotropic loci for compensating the missing genetic heritability of CRC. METHODS: We conducted a systematic genome-wide pleiotropy scan to appraise associations between cancer-related genetic variants and CRC risk among European populations. Single nucleotide polymorphism (SNP)-set...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36928917
DOI: 10.1093/hmg/ddad044
PMCID: PMC10244225

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