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Plasma Proteomic Signature Predicts Myeloid Neoplasm Risk

6 Mar 2024

Abstract excerpt

PURPOSE: Clonal hematopoiesis (CH) is thought to be the origin of myeloid neoplasms (MN). Yet, our understanding of the mechanisms driving CH progression to MN and clinical risk prediction of MN remains limited. The human proteome reflects complex interactions between genetic and epigenetic regulation of biological systems. We hypothesized that the plasma proteome might predict MN risk and inform our...

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PMID: 38446993
DOI: 10.1158/1078-0432.ccr-23-3468

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