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Article

Disruption of placental ACKR3 impairs growth and hematopoietic development of offspring.

Development (Cambridge, England) - 15 Feb 2024

Fukuoka Ayumi, Wilson Gillian J, Pitmon Elise, Koumbas Foley Lily, Johnsson Hanna, Pingen Marieke, Graham Gerard J

Abstract excerpt

ACKR3 scavenges and degrades the stem cell recruiting chemokine CXCL12, which is essential for proper embryonic and, in particular, haematopoietic development. Here, we demonstrate strong expression of ACKR3 on trophoblasts. Using a maternally administered pharmacological blocker and Cre-mediated genetic approaches, we demonstrate that trophoblast ACKR3 is essential for preventing movement of CXCL12 from the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38300826
DOI: 10.1242/dev.202333
PMCID: PMC10911115

Genes

ACKR3
CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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