Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A GCSFR/CSF3R zebrafish mutant models the persistent basal neutrophil deficiency of severe congenital neutropenia.

Scientific reports - 10 Mar 2017

Pazhakh Vahid, Clark Sharon, Keightley M Cristina, Lieschke Graham J

Abstract excerpt

Granulocyte colony-stimulating factor (GCSF) and its receptor (GCSFR), also known as CSF3 and CSF3R, are required to maintain normal neutrophil numbers during basal and emergency granulopoiesis in humans, mice and zebrafish. Previous studies identified two zebrafish CSF3 ligands and a single CSF3 receptor. Transient antisense morpholino oligonucleotide knockdown of both these ligands and receptor reduces...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital Bone Marrow Failure Syndromes
Share to Granulocyte Colony-Stimulating Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haploinsufficiency

Share to Leukocyte Count

Share to Morpholinos

Share to Neutropenia

Share to Neutrophils

Share to Receptors, Colony-Stimulating Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 28281657
DOI: 10.1038/srep44455
PMCID: PMC5345067

Genes

CSF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A GCSFR/CSF3R zebrafish mutant models the persistent basal neutrophil deficiency of severe congenital neutropenia.PMID 28281657Read ↗

Human 'knockouts' of CSF3 display severe congenital neutropenia.Semantic proximity Read ↗

Granulocyte colony-stimulating factor receptor signaling in severe congenital neutropenia, chronic neutrophilic leukemia, and related malignancies.Semantic proximity Read ↗

Inherited biallelic CSF3R mutations in severe congenital neutropeniaSemantic proximity Read ↗

A JAGN1-associated severe congenital neutropenia zebrafish model revealed an altered G-CSFR signaling and UPR activation.Semantic proximity Read ↗

G-CSF receptor mutations in patients with congenital neutropenia.Semantic proximity Read ↗

Increased granulocyte colony-stimulating factor responsiveness but normal resting granulopoiesis in mice carrying a targeted granulocyte colony-stimulating factor receptor mutation derived from a patient with severe congenital neutropenia.Semantic proximity Read ↗

A zebrafish model for HAX1-associated congenital neutropenia.Semantic proximity Read ↗

A congenital CSF3R mutation in chronic neutropenia reveals a vital role for a cytokine receptor extracellular hinge motif in the response to granulocyte colony-stimulating factor.Semantic proximity Read ↗

Truncated CSF3 receptors induce pro-inflammatory responses in severe congenital neutropenia.Semantic proximity Read ↗

Role of CSF3R mutations in the pathomechanism of congenital neutropenia and secondary acute myeloid leukemia.Semantic proximity Read ↗

Colony stimulating factor 1 signaling regulates myeloid fates in zebrafish via distinct action of its receptors and ligandsSemantic proximity Read ↗

Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropenia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.