Article

Pregnancy loss due to early developmental defects in lupus mice expressing human TLR8

2026-02-09

Abstract excerpt

Anti-phospholipid (APL) autoantibodies confer a high risk for adverse pregnancy outcomes, especially in Systemic Lupus Erythematosus (SLE). While human TLR8 (huTLR8) has been implicated in APL antibody-mediated placental injury in vitro , its in vivo role in pregnancy is unexplored. We report a novel mouse model of pregnancy loss in SLE-prone mice expressing huTLR8. Placental analysis revealed early developmenta...

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Literature Corpus work: 7673ec19-8089-518c-a8d0-4dd63e6b7482
DOI: 10.64898/2026.02.07.701591

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