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Article

Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts.

Journal of cellular physiology - 1 May 2016

Tan Yinfei, Xin Xiaoban, Coffey Francis J, Wiest David L, Dong Lily Q, Testa Joseph R

Abstract excerpt

Although Appl1 and Appl2 have been implicated in multiple cellular activities, we and others have found that Appl1 is dispensable for mouse embryonic development, suggesting that Appl2 can substitute for Appl1 during development. To address this possibility, we generated conditionally targeted Appl2 mice. We found that ubiquitous Appl2 knockout (Appl2-/-) mice, much like Appl1-/- mice, are viable and grow...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hematopoietic Stem Cells

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Share to Proto-Oncogene Proteins c-akt

Source

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Identifiers

PMID: 26445298
DOI: 10.1002/jcp.25211
PMCID: PMC4728037

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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