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Article

Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease

28 Oct 2005

Abstract excerpt

The suppressor of cytokine-signaling (SOCS) proteins act as negative-feedback inhibitors of cytokine and growth-factor-induced signal transduction. In vivo studies have implicated SOCS3 as a negative regulator of signaling downstream of gp130, the receptor subunit shared by IL-6-like cytokines. Mice lacking SOCS3 die at midgestation because of placental failure, and SOCS3 ablation in a cell-type-specific manner...

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Identifiers

PMID: 16258063
DOI: 10.1073/pnas.0508023102

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Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory diseasePMID 16258063Read ↗

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Rapid Inflammation in Mice Lacking Both SOCS1 and SOCS3 in Hematopoietic CellsSemantic proximity Read ↗

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