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Article

Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands.

Nature genetics - 1 Jun 2021

Weinberg Daniel N, Rosenbaum Phillip, Chen Xiao, Barrows Douglas, Horth Cynthia, Marunde Matthew R, Popova Irina K, Gillespie Zachary B, Keogh Michael-Christopher, Lu Chao, Majewski Jacek, Allis C David

Abstract excerpt

Precise deposition of CpG methylation is critical for mammalian development and tissue homeostasis and is often dysregulated in human diseases. The localization of de novo DNA methyltransferase DNMT3A is facilitated by its PWWP domain recognizing histone H3 lysine 36 (H3K36) methylation1,2 and is normally depleted at CpG islands (CGIs)3. However, methylation of CGIs regulated by Polycomb repressive complexes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33986537
DOI: 10.1038/s41588-021-00856-5
PMCID: PMC8283687

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