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DNMT3b Dysfunction Promotes DNA cleavages at Centromeric R-loops to Increase Centromere Instability

2020-06-04

Abstract excerpt

<h4>ABSTRACT</h4> This study investigates how DNA methyltransferase 3b (DNMT3b) dysfunction causes genome instability. We showed that in DNMT3b deficient cells, R-loops contribute to prominent γH2AX signal, which was mapped to repetitive satellite sequences including centromere regions. By ChIP and DRIP analyses, our data revealed that centromeric R-loops in DNMT3b deficient cells are removed by XPG/XPF, thus gen...

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Literature Corpus work: 60267c47-44a9-5d55-a73e-f91fe73bc5b4
DOI: 10.1101/2020.06.04.133272

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