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Unraveling the epigenetic code: human kidney DNA methylation and chromatin dynamics in renal disease development

29 Jan 2024

Abstract excerpt

Epigenetic changes may fill a critical gap in our understanding of kidney disease development, as they not only reflect metabolic changes but are also preserved and transmitted during cell division. We conducted a genome-wide cytosine methylation analysis of 399 human kidney samples, along with single-nuclear open chromatin analysis on over 60,000 cells from 14 subjects, including controls, and diabetes and...

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PMID: 38287030
DOI: 10.1038/s41467-024-45295-y

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