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Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease

5 Jun 2019

Abstract excerpt

Epigenetic changes might provide the biological explanation for the long-lasting impact of metabolic alterations of diabetic kidney disease development. Here we examined cytosine methylation of human kidney tubules using Illumina Infinium 450 K arrays from 91 subjects with and without diabetes and varying degrees of kidney disease using a cross-sectional design. We identify cytosine methylation changes associated...

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PMID: 31165727
DOI: 10.1038/s41467-019-10378-8

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