Article
Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci.
Genome medicine - 30 Apr 2021
Breeze Charles E, Batorsky Anna, Lee Mi Kyeong, Szeto Mindy D, Xu Xiaoguang, McCartney Daniel L, Jiang Rong, Patki Amit, Kramer Holly J, Eales James M, Raffield Laura, Lange Leslie, Lange Ethan, Durda Peter, Liu Yongmei, Tracy Russ P, Van Den Berg David, Evans Kathryn L, Kraus William E, Shah Svati, Tiwari Hermant K, Hou Lifang, Whitsel Eric A, Jiang Xiao, Charchar Fadi J, Baccarelli Andrea A, Rich Stephen S, Morris Andrew P, Irvin Marguerite R, Arnett Donna K, Hauser Elizabeth R, Rotter Jerome I, Correa Adolfo, Hayward Caroline, Horvath Steve, Marioni Riccardo E, Tomaszewski Maciej, Beck Stephan, Berndt Sonja I, London Stephanie J, Mychaleckyj Josyf C, Franceschini Nora
Abstract excerpt
BACKGROUND: DNA methylation (DNAm) is associated with gene regulation and estimated glomerular filtration rate (eGFR), a measure of kidney function. Decreased eGFR is more common among US Hispanics and African Americans. The causes for this are poorly understood. We aimed to identify trans-ethnic and ethnic-specific differentially methylated positions (DMPs) associated with eGFR using an agnostic, genome-wide...
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