Genome-wide DNA methylation analysis revealed epigenetic mechanism underlying end stage renal disease

Abstract excerpt

<title>Abstract</title> <p>End-stage renal disease (ESRD) remains to be a major clinical challenge with persistently high morbidity and mortality, and its molecular mechanisms, particularly those shared among diverse primary kidney diseases during the progression to ESRD, have not been studied. Here we conducted a large-scale two-stage epigenome-wide association study of ESRD in two independent cohorts consisting...

Topics

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• Adenosine and Purinergic Signaling
• Birth, Development, and Health
• Chronic Kidney Disease and Diabetes
• Dialysis and Renal Disease Management
• Epigenetics and DNA Methylation
• Folate and B Vitamins Research
• Genetic Syndromes and Imprinting
• Renal and Vascular Pathologies

Identifiers and source

Literature Corpus work

086a2778-f87a-5f91-981d-9d2e689bf8fd

DOI

10.21203/rs.3.rs-7071877/v1