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Article

Systematic integrated analysis of genetic and epigenetic variation in diabetic kidney disease.

Proceedings of the National Academy of Sciences of the United States of America - 17 Nov 2020

Sheng Xin, Qiu Chengxiang, Liu Hongbo, Gluck Caroline, Hsu Jesse Y, He Jiang, Hsu Chi-Yuan, Sha Daohang, Weir Matthew R, Isakova Tamara, Raj Dominic, Rincon-Choles Hernan, Feldman Harold I, Townsend Raymond, Li Hongzhe, Susztak Katalin

Abstract excerpt

Poor metabolic control and host genetic predisposition are critical for diabetic kidney disease (DKD) development. The epigenome integrates information from sequence variations and metabolic alterations. Here, we performed a genome-wide methylome association analysis in 500 subjects with DKD from the Chronic Renal Insufficiency Cohort for DKD phenotypes, including glycemic control, albuminuria, kidney function,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33144501
DOI: 10.1073/pnas.2005905117
PMCID: PMC7682409

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