Genome-wide DNA methylation analysis revealed epigenetic mechanism underlying end-stage renal disease

Abstract excerpt

Abstract End-stage renal disease (ESRD) remains to be a major clinical challenge with persistently high morbidity and mortality, and its molecular mechanisms, particularly those shared among diverse primary kidney diseases during the progression to ESRD, have not been studied. Here we conducted a large-scale two-stage epigenome-wide association study of ESRD in two independent cohorts consisting of 704 controls an...

Topics

Open a Topic to create a Post that cites this publication.

• Chronic Kidney Disease and Diabetes
• Dialysis and Renal Disease Management
• Renal and Vascular Pathologies

Identifiers and source

Literature Corpus work

6071a1a5-0f53-55c0-9b7d-422908198c9c

DOI

10.1038/s41467-026-76153-8