Article
MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution.
Nature genetics - 1 Oct 2024
Puttick Clare, Jones Thomas P, Leung Michelle M, Galvez-Cancino Felipe, Liu Jiali, Varas-Godoy Manuel, Rowan Andrew, Pich Oriol, Martinez-Ruiz Carlos, Bentham Robert, Dijkstra Krijn K, Black James R M, Rosenthal Rachel, Kanu Nnennaya, Litchfield Kevin, Salgado Roberto, Moore David A, Van Loo Peter, Jamal-Hanjani Mariam, Quezada Sergio A, Swanton Charles, McGranahan Nicholas
Abstract excerpt
Disruption of the class I human leukocyte antigen (HLA) molecules has important implications for immune evasion and tumor evolution. We developed major histocompatibility complex loss of heterozygosity (LOH), allele-specific mutation and measurement of expression and repression (MHC Hammer). We identified extensive variability in HLA allelic expression and pervasive HLA alternative splicing in normal lung and...
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