Article
The multilevel extensive diversity across the cynomolgus macaque captured by ultra-deep adaptive immune receptor repertoire sequencing.
Science advances - 26 Jan 2024
Zhu Yan, Tang Haipei, Xie Wenxi, Chen Sen, Zeng Huikun, Lan Chunhong, Guan Junjie, Ma Cuiyu, Yang Xiujia, Wang Qilong, Wei Lai, Zhang Zhenhai, Yu Xueqing
Abstract excerpt
The extent to which AIRRs differ among and within individuals remains elusive. Via ultra-deep repertoire sequencing of 22 and 25 tissues in three cynomolgus macaques, respectively, we identified 84 and 114 novel IGHV and TRBV alleles, confirming 72 (85.71%) and 100 (87.72%) of them. The heterogeneous V gene usage patterns were influenced, in turn, by genetics, isotype (for BCRs only), tissue group, and tissue. A...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.